Colin Quinn (comedian, actor, author, former Saturday Night Live "Weekend Update" host) stops by to discuss the science of stand-up and his journey toward sobriety. He takes us through his comedic evolution, from heckling teachers in school to pursuing comedy full-time after getting sober. Colin opens up about his unrecognized issues manifesting during his time at SNL, his experiences with jungian therapy, and his belief in purgatory. Mayim and Colin discuss sensory reactions to comedic timing, comedic sensibilities informed by demographics, and the consequences of ego.