Mayim discusses the neurobiology of homosexuality including research which highlights neuroanatomical differences between the homosexual and heterosexual brain. Beloved comedian Leslie Jordan shares his personal struggles with crystal meth and alcohol as well as growing up gay in the south at a time when no one talked about it. He reflects on entering his first serious relationship very recently and explores how sobriety has allowed him access to aspects of his mental health and love life he had never been able to experience.