Rosie O’Donnell (The Rosie O’Donnell Show, A League of Their Own, Onward podcast) discusses the ripple effects of her mom passing when Rosie was a child, the emergence of the first LGBTQ movement, and the emotional highs and lows of becoming an activist for gay parents. She explains how she got into stand-up comedy as a teenager, the prevalence of alcoholism and abuse on her father's side of the family, and how losing mother made her strive to please the adults in her life and putting on a tough persona as a cry for love. Rosie opens up about the differences between her coming out process and what it’s like to come out now, her intense quest for spirituality, and navigating her youngest daughter’s autism diagnosis & what her daughter has taught her about inclusivity. She describes the odd circumstances of her heart attack and how symptoms differ between men and women, what it was like to address her ex-wife’s suicide as a public person, and how alcoholism varies from drug addiction. Mayim and Rosie break down adoption trauma, nature vs nurture in adoption, why women’s rights affect everything, and Rosie’s opinion on The View after all these years.