Tig Notaro ( Tig Notaro: Drawn , Don't Ask Tig podcast, Tig & Cheryl: True Story podcast) drops by to discuss how her chaotic childhood and health struggles shaped her into the talented stand-up comedian she is today. She details her musical background, dropping out of school, and the confusing feelings she had about her sexuality. She opens up about the most difficult time in her life - dealing with a serious medical condition, losing her mother, and going through a breakup, all within the span of a few months. Tig reveals the things that bring her comfort in the mental health space before Mayim breaks down the neuroscience behind coping mechanisms in another installment of Ask Mayim Anything.