A Neurological Case Study: The Man Without Memory

Born in 1926, Henry Molaison, better known as “HM,” has become one of neurology’s most well-known case studies...

Born in 1926, Henry Molaison, better known as “HM,” has become one of neurology’s most well-known case studies. HM suffered from a severe form of epilepsy. Desperate for a solution, neurosurgeon, Dr. William Scoville, performed an experimental surgery where he removed portions of both the left and right medial temporal lobe to reduce the frequency of seizures (Loring & Hermann, 2017).

Following the procedure, HM developed a condition called “anterograde amnesia.” This means that he lost the ability to form new memories. Interestingly, while the generation of new memories was affected, many of his other mental capacities were not. He still performed well on intelligence and motor skill learning. To explain this in a more digestible way, let me give you a hypothetical scenario. Imagine HM began playing basketball after his surgery. If he played each day, he would get better and better, maintaining the skills he learned, even though he would have no memory of actually playing basketball. This is meaningful because it showed scientists that the generation of new episodic memories (memories about events) was not necessary for motor learning (Bigya et al., 2014; Jacopo et al., 2014).

Sadly, HM’s condition made his life very difficult. Each day was a challenge for both him and his loved ones as he tried to navigate the world without the ability to generate new episodic memories. The devastating side-effect of his surgery taught neuroscientists a lot about some of the basic memory systems of the brain. Several of the brain structures removed, the hippocampus and parahippocampal gyrus, which were later able to be attributed to the formation of new episodic memories (Shaw, Pattanayak, & Sager, 2014; Squire, 2009; Squire & Wixted, 2011). Though HM died in 2008 at the age of 82, his legacy will live on in the scientific study of learning memory.

Sources:

  • Loring, D. W., & Hermann, B. (2017). Remembering H.M.: Review of “PATIENT H.M.: A Story of Memory, Madness, and Family Secrets.” Archives of Clinical Neuropsychology, 32(4), 501–505. https://doi.org/10.1093/arclin/acx041
  • Squire, L. R. (2009). The legacy of patient H.M. for neuroscience. Neuron, 61(1), 6–9. https://doi.org/10.1016/j.neuron.2008.12.023
  • Squire, L. R., & Wixted, J. T. (2011). The cognitive neuroscience of human memory since H.M. Annual Review of Neuroscience, 34, 259–288. https://doi.org/10.1146/annurev-neuro-061010-113720
  • Jacopo Annese, Schenker-Ahmed, N. M., Hauke Bartsch, Maechler, P., Sheh, C., Thomas, N., Junya Kayano, Ghatan, A., Bresler, N., Frosch, M. P., Klaming, R., & Corkin, S. (2014). Postmortem examination of patient H.M.’s brain based on histological sectioning and digital 3D reconstruction. Nature Communications, 5(1), 1–9. https://doi.org/10.1038/ncomms4122
  • Bigya Shah, Raman Deep Pattanayak, & Rajesh Sagar. (2014). The study of patient Henry Molaison and what it taught us over past 50 years: Contributions to neuroscience. Journal of Mental Health and Human Behaviour, 19(2), 91. https://doi.org/10.4103/0971-8990.153719
  • Shah B, Pattanayak RD, Sagar R. The study of patient henry Molaison and what it taught us over past 50 years: Contributions to neuroscience. J Mental Health Hum Behav 2014;19:91-3


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